After leaving rehab early, Jackie finds sobriety and relative happiness, but that is the calm before the storm. With her marriage coming to an end, a careless accident sends Jackie to her own all Saints Hospital for emergency care. While recovering, she meets NYC policeman Frank Verelli, whose flirtatious advances may lead Jackie into uncharted territory: dating.

Jackie Peyton is a sharp-tongued and quick-witted nurse who is trying to survive the chaotic grind of saving lives in a hectic New York City hospital. Jackie's a woman of substance who knows how to handle it all. With a white lie here, a bent rule there, and a steady dose of pain relievers for her chronic back pain, Jackie does whatever it takes to get the job done.